Online first articles

C. Jr., D. Dowling, J. Zhou
Collection of EBioMedicine (2017).

V. Serebruany
Collection of EBioMedicine (2017).

I. Astsaturov
Collection of EBioMedicine (2017).

E. Wild
Collection of EBioMedicine (2017).

D. Grattan
Collection of EBioMedicine (2017).

R. Zhao, B. Choi, M. Lee, A. Bode, Z. Dong
Collection of EBioMedicine (2017).

Abstract
Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which [...]

J. Wu, M. Gao, S. Rice, C. Tsang, J. Beggs, D. Turner, G. Li, B. Yang, K. Xia, F. Gao, S. Qiu, Q. Liu, J. Kerrigan
Collection of EBioMedicine (2017).

Abstract
Human hypothalamic hamartoma (HH) is a rare subcortical lesion associated with treatment-resistant epilepsy. Cellular mechanisms responsible for epileptogenesis are unknown. [...]

B. Wolozin, T. Ikezu
Collection of EBioMedicine (2017).

. Wei, H. Guo, M. Ma, R. Markham, X. Yu
Collection of EBioMedicine (2017).

Abstract
Recent studies have identified human myxovirus resistance protein 2 (MxB or Mx2) as an interferon induced inhibitor of HIV-1 replication. However, whether HIV-1 can overcome [...]

V. Walker-Sperling, C. Pohlmeyer, P. Tarwater, J. Blankson
Collection of EBioMedicine (2017).

Abstract
Shock and kill strategies involving the use of small molecules to induce viral transcription in resting CD4 + T cells (shock) followed by immune mediated clearance of the [...]

L. Vranckx, J. Demeulemeester, S. Saleh, A. Boll, G. Vansant, R. Schrijvers, C. Weydert, E. Battivelli, E. Verdin, A. Cereseto, F. Christ, R. Gijsbers, Z. Debyser
Collection of EBioMedicine (2017).

Abstract
Persistence of latent, replication-competent Human Immunodeficiency Virus type 1 (HIV-1) provirus is the main impediment towards a cure for HIV/AIDS (Acquired Immune Deficiency [...]

H. Vanderven, F. Ana-Sosa-Batiz, S. Jegaskanda, S. Rockman, K. Laurie, I. Barr, W. Chen, B. Wines, P. Hogarth, T. Lambe, S. Gilbert, M. Parsons, S. Kent
Collection of EBioMedicine (2017).

Abstract
The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well characterised for T cell immunity, but whether they also elicit functional antibodies [...]

S. Ushiama, Y. Ishimaru, M. Narukawa, M. Yoshioka, C. Kozuka, N. Watanabe, M. Tsunoda, N. Osakabe, T. Asakura, H. Masuzaki, K. Abe
Collection of EBioMedicine (2017).

Abstract
Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred [...]

R. Uauy, D. Suri, S. Ghosh, A. Kurpad, I. Rosenberg
Collection of EBioMedicine (2017).

K. Tschapalda, Y. Zhang, L. Liu, K. Golovnina, T. Schlemper, T. Eichmann, M. Lal-Nag, U. Sreenivasan, J. McLenithan, S. Ziegler, C. Sztalryd, A. Lass, D. Auld, B. Oliver, H. Waldmann, Z. Li, M. Shen, M. Boxer, M. Beller
Collection of EBioMedicine (2017).

Abstract
Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications [...]

T. Sinnberg, E. Makino, M. Krueger, A. Velic, B. Macek, U. Rothbauer, N. Groll, O. Pötz, S. Czemmel, H. Niessner, F. Meier, K. Ikenberg, C. Garbe, B. Schittek
Collection of EBioMedicine (2017).

Abstract
Acquired resistance to second generation BRAF inhibitors (BRAFis), like vemurafenib is limiting the benefits of long term targeted therapy for patients with malignant melanomas [...]

Y. Shen, C. Pang, Y. Wu, D. Li, C. Wan, Z. Liao, T. Yang, L. Chen, F. Wen
Collection of EBioMedicine (2017).

Abstract
The usefulness of bronchoalveolar lavage fluid (BALF) CD4/CD8 ratio for diagnosing sarcoidosis has been reported in many studies with variable results. Therefore, we performed [...]

S. Serrano-Villar, D. Rojo, M. Martínez-Martínez, S. Deusch, J. Vázquez-Castellanos, R. Bargiela, T. Sainz, M. Vera, S. Moreno, V. Estrada, M. Gosalbes, A. Latorre, J. Seifert, C. Barbas, A. Moya, M. Ferrer
Collection of EBioMedicine (2017).

Abstract
While changes in gut microbial populations have been described in human immuno-deficiency virus (HIV)-infected patients undergoing antiretroviral therapy (ART), the mechanisms [...]

M. Roerecke, R. Nanau, J. Rehm, M. Neuman
Collection of EBioMedicine (2017).

Abstract
Fatty liver (hepatic steatosis) is one of the most common diseases globally, with increasing prevalence. The role of alcohol consumption in the development of hepatic steatosis [...]

C. Psomas, M. Younas, C. Reynes, R. Cezar, P. Portalès, E. Tuaillon, A. Guigues, C. Merle, N. Atoui, C. Fernandez, V. Moing, C. Barbuat, G. Marin, N. Nagot, A. Sotto, J. Eliaou, R. Sabatier, J. Reynes, P. Corbeau
Collection of EBioMedicine (2017).

Abstract
Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, [...]

M. Proietti, D. Lane, G. Lip
Collection of EBioMedicine (2017).

Abstract
Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study [...]

L. Osborne, L. WegenerParfrey
Collection of EBioMedicine (2017).

J. Munkley, D. Vodak, K. Livermore, K. James, B. Wilson, B. Knight, P. Mccullagh, J. Mcgrath, M. Crundwell, L. Harries, H. Leung, C. Robson, I. Mills, P. Rajan, D. Elliott
Collection of EBioMedicine (2017).

Abstract
Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control [...]

G. Metodieva, S. Adoki, B. Lausen, M. Metodiev
Collection of EBioMedicine (2017).

Abstract
SCRIB is a polarity regulator known to be abnormally expressed in cancer at the protein level. Here we report that, in breast cancer, an additional and hidden dimension of [...]

T. Mesplède, M. Wainberg
Collection of EBioMedicine (2017).

M. Martínez-Hoyos, E. Perez-Herran, G. Gulten, L. Encinas, D. Álvarez-Gómez, E. Alvarez, S. Ferrer-Bazaga, A. García-Pérez, F. Ortega, I. Angulo-Barturen, J. Rullas-Trincado, D. Ruano, P. Torres, P. Castañeda, S. Huss, R. Menéndez, S. Valle, L. Ballell, D. Barros, S. Modha, N. Dhar, F. Signorino-Gelo, J. McKinney, J. García-Bustos, J. Lavandera, J. Sacchettini, M. Jimenez, N. Martín-Casabona, J. Castro-Pichel, A. Mendoza-Losana
Collection of EBioMedicine (2017).

Abstract
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together [...]

A. Lonardo, S. Ballestri, D. Romagnoli, F. Nascimbeni
Collection of EBioMedicine (2017).

Y. Liu, B. Wang, W. Zhang, J. Huang, B. Li, M. Zhang, L. Jiang, J. Li, M. Wang, Y. Dai, Z. Zhang, Q. Wang, J. Kong, B. Chen, Y. Zhu, X. Weng, Z. Shen, J. Li, J. Wang, X. Yan, Y. Li, Y. Liang, L. Liu, X. Chen, W. Zhang, J. Yan, J. Hu, S. Shen, J. Chen, L. Gu, D. Pei, Y. Li, G. Wu, X. Zhou, R. Ren, . Cheng, J. Yang, K. Wang, S. Wang, J. Zhang, J. Mi, C. Pui, J. Tang, Z. Chen, S. Chen
Collection of EBioMedicine (2017).

Abstract
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing and copy number [...]

N. Lin, O. Gonzalez, L. Registre, C. Becerril, B. Etemad, H. Lu, X. Wu, S. Lockman, M. Essex, S. Moyo, D. Kuritzkes, M. Sagar
Collection of EBioMedicine (2017).

Abstract
Although both C-C chemokine receptor 5 (CCR5)- and CXC chemokine receptor 4 (CXCR4)-using HIV-1 strains cause AIDS, the emergence of CXCR4-utilizing variants is associated [...]

A. Illendula, J. Gilmour, J. Grembecka, V. Tirumala, A. Boulton, A. Kuntimaddi, C. Schmidt, L. Wang, J. Pulikkan, H. Zong, M. Parlak, C. Kuscu, A. Pickin, Y. Zhou, Y. Gao, L. Mishra, M. Adli, L. Castilla, R. Rajewski, K. Janes, M. Guzman, C. Bonifer, J. Bushweller
Collection of EBioMedicine (2017).

Abstract
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could [...]

M. Hassane, C. Paget
Collection of EBioMedicine (2017).

E. Gazzerro, P. Striano
Collection of EBioMedicine (2017).

T. Friedrich, M. Söhn, T. Gutting, K. Janssen, H. Behrens, C. Röcken, M. Ebert, E. Burgermeister
Collection of EBioMedicine (2017).

Abstract
Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human [...]

K. Chng, S. Chan, A. Ng, C. Li, A. Jusakul, D. Bertrand, A. Wilm, S. Choo, D. Tan, K. Lim, R. Soetinko, C. Ong, D. Duda, S. Dima, I. Popescu, C. Wongkham, Z. Feng, K. Yeoh, B. Teh, P. Yongvanit, S. Wongkham, V. Bhudhisawasdi, N. Khuntikeo, P. Tan, C. Pairojkul, J. Ngeow, N. Nagarajan
Collection of EBioMedicine (2017).

Abstract
Cholangiocarcinoma (CCA) is the primary cancer of the bile duct system. The role of bile duct tissue microbiomes in CCA tumorigenesis is unestablished. To address this, sixty [...]

C. Brégnard, J. Guerra, S. Déjardin, F. Passalacqua, M. Benkirane, N. Laguette
Collection of EBioMedicine (2017).

Abstract
Fanconi Anemia (FA) is a genetic disorder characterized by elevated cancer susceptibility and pro-inflammatory cytokine production. Using SLX4FANCP deficiency as a working [...]

F. Bolduc, A. Lau, C. Rosenfelt, S. Langer, N. Wang, L. Smithson, D. Lefebvre, R. Alexander, C. Dickson, A. Li, A. Becker, P. Subbarao, S. Turvey, J. Pei, M. Sears, P. Mandhane
Collection of EBioMedicine (2017).

Abstract
In-utero nutrition is an under-studied aspect of cognitive development. Fruit has been an important dietary constituent for early hominins and humans. Among 808 eligible CHILD-Edmonton [...]

M. Berendsen, J. Smits, M. Netea, A. Ven
Collection of EBioMedicine (2017).

Abstract
Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as [...]

I. Audenhove, J. Gettemans
Collection of EBioMedicine (2017).

Abstract
Since their discovery, nanobodies have been used extensively in the fields of research, diagnostics and therapy. These antigen binding fragments, originating from Camelid [...]

W. Altarche-Xifro, U. Vicino, M. Muñoz-Martin, A. Bortolozzi, J. Bové, M. Vila, M. Cosma
Collection of EBioMedicine (2017).

Abstract
Parkinsons disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive [...]

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